Invitrogen

PDE2A Polyclonal Antibody

Name: PDE2A Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-56665

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View all (42) PDE2A antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (3)
Advanced Verification (1)

PDE2A Antibody in Immunohistochemistry (IHC)

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PDE2A Antibody (PA5-56665) in IHC

Immunohistochemical staining of PDE2A in human spleen and pancreas tissues using PDE2A Polyclonal Antibody (Product # PA5-56665). Corresponding PDE2A RNA-seq data are presented for the same tissues.

Product Image Gallery

PDE2A Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of PDE2A demonstrates antibody specificity. Immunohistochemical analysis of PDE2A using anti-PDE2A Polyclonal Antibody (Product # PA5-56665), shows significant staining of PDE2A in human spleen and shows minimal or weak staining in human pancreas tissues. The relative expression levels of PDE2A within each tissue is shown using RNA-Seq. {RE}

Immunogen image

Immunogen Image PDE2A Polyclonal Antibody

Product Details

PA5-56665

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PDE2A. Recombinant protein control fragment (Product #RP-104153).

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2645327

Product Specific Information

Immunogen sequence: EHVIQHCFHY TSTVLTSTLA FQKEQKLKCE CQALLQVAKN LFTHLDDVSV LLQEIITEAR NLSNAEICSV FLLDQNELVA KVFDGGVVDD ESYEIRIPA

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 97%.

Target Information

PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE) and three isoforms of PDE2A have been reported (PDE2A1, PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localized in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; phosphodiesterase 2A, cGMP-stimulated

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Gene Aliases: CGS-PDE; cGSPDE; PDE2A; PDE2A1; PED2A4

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UniProt ID: (Human) O00408

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Entrez Gene ID: (Human) 5138

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Function(s)

cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity calcium channel activity protein binding drug binding cAMP binding cGMP binding TPR domain binding protein homodimerization activity metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity

Process(es)

negative regulation of transcription from RNA polymerase II promoter cAMP catabolic process protein targeting to mitochondrion metabolic process cAMP-mediated signaling cGMP-mediated signaling negative regulation of cAMP biosynthetic process negative regulation of protein import into nucleus, translocation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus negative regulation of vascular permeability positive regulation of vascular permeability cGMP catabolic process positive regulation of inflammatory response establishment of endothelial barrier calcium ion transmembrane transport cellular response to mechanical stimulus cellular response to cGMP cellular response to transforming growth factor beta stimulus

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PDE2A Polyclonal Antibody

PDE2A Antibody (PA5-56665) in IHC

Product Details

PA5-56665

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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