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Invitrogen
PD-L1 (CD274) Chimeric Recombinant Rabbit Monoclonal Antibody (332M7)
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FIGURE: 1 / 2
PD-L1 (CD274) Chimeric Antibody (MA5-51620) in ICC/IF
Product Details
MA5-51620
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Product Specific Information
This antibody strongly binds human and cynomolgus monkey PD-L1 and shows weak binding for mouse PD-L1. PD-L1 is highly expressed in many human tumors. PD-L1 exerts an immune suppressive signal through binding to PD-1 and B7.1, and tumor expression of PD-L1 can mediate cancer immune evasion. Blocking this pathway, therefore provides a rationale for cancer immunotherapy.
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: B7 homolog 1; B7-H1; CD274; CD274 antigen; CD274 molecule; hypothetical protein; PD-L1; PDCD1 ligand 1; pdl-1; Programmed cell death 1 ligand 1; programmed cell death ligand 1; programmed death ligand 1; sCD274; soluble CD274; soluble PD L1; sPD L1
Gene Aliases: A530045L16Rik; B7-H; B7H1; CD274; EGM_07025; PD-L1; PDCD1L1; PDCD1LG1; PDL1
UniProt ID: (Human) Q9NZQ7, (Mouse) Q9EP73
Entrez Gene ID: (Cynomolgus monkey) 102145573, (Human) 29126, (Mouse) 60533
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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