Invitrogen

PCSK9 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
PCSK9 Polyclonal Antibody

Product Details

PA5-96836

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 590-692 of human Proprotein Convertase 9(PCSK9) (NP_7775962)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.63 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808638

Product Specific Information

Positive Samples: SW480; Cellular Location: Cell surface, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome

Immunogen sequence: GHREASIHAS CCHAPGLECK VKEHGIPAPQ EQVTVACEEG WTLTGCSALP GTSHVLGAYA VDNTCVVRSR DVSTTGSTSE GAVTAVAICC RSRHLAQASQ ELQ

Target Information

PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: convertase subtilisin; convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9

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Gene Aliases: AI415265; AI747682; FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; PCSK9; PSEC0052

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UniProt ID: (Human) Q8NBP7, (Rat) P59996, (Mouse) Q80W65

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Entrez Gene ID: (Human) 255738, (Rat) 298296, (Mouse) 100102

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Function(s)
serine-type endopeptidase activity protein binding sodium channel inhibitor activity low-density lipoprotein particle binding receptor inhibitor activity apolipoprotein binding very-low-density lipoprotein particle binding apolipoprotein receptor binding protein self-association poly(A) RNA binding low-density lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding peptidase activity serine-type peptidase activity hydrolase activity
Process(es)
kidney development liver development negative regulation of receptor recycling positive regulation of receptor internalization proteolysis triglyceride metabolic process phospholipid metabolic process apoptotic process lysosomal transport cholesterol metabolic process cellular response to starvation regulation of receptor activity negative regulation of low-density lipoprotein particle clearance protein processing protein autoprocessing neurogenesis neuron differentiation low-density lipoprotein receptor particle metabolic process low-density lipoprotein particle receptor catabolic process regulation of low-density lipoprotein particle receptor catabolic process cellular response to insulin stimulus lipoprotein metabolic process cholesterol homeostasis regulation of neuron apoptotic process positive regulation of neuron apoptotic process lipid metabolic process steroid metabolic process positive regulation of low-density lipoprotein particle receptor catabolic process negative regulation of receptor activity negative regulation of sodium ion transmembrane transporter activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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