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Invitrogen
PCP4 Polyclonal Antibody
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Product Details
PA5-52209
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
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Product Specific Information
Immunogen sequence: GAGATNGKDK TSGENDGQKK VQEEFDIDMD APETERAAVA IQSQFRKFQK KK
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: brain specific polypeptide PEP19; Brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Calmodulin regulator protein PCP4; Purkinje cell protein 4
Gene Aliases: P16Rimb19; Pcp-4; PCP4; PEP-19; PEP19
UniProt ID: (Human) P48539, (Mouse) P63054
Entrez Gene ID: (Human) 5121, (Mouse) 18546
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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