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Invitrogen
P2X2 Polyclonal Antibody
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Product Details
PA5-31318
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
Recommended positive controls: A549, HepG2, mouse brain.
Predicted reactivity: Mouse (81%), Rat (80%), Bovine (86%), Guinea pig (83%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: ATP receptor; MGC129601; P2X purinoceptor 2; P2X Receptor, subunit 2; P2X2; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 2; purinergic receptor P2X, ligand-gated ion channel, 2
Gene Aliases: DFNA41; P2RX2; P2X2; P2X2a
UniProt ID: (Human) Q9UBL9, (Mouse) Q8K3P1
Entrez Gene ID: (Human) 22953, (Mouse) 231602
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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