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Proteintech
Occludin Monoclonal Antibody (1D3C4)
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Product Details
66378-1-IG
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: RKMDRYDKS NILWDKEHIY DEQPPNVEEW VKNVSAGTQD VPSPPSDYVE RVDSPMAYSS NGKVNDKRFY PESSYKSTPV PEVVQELPLT SPVDDFRQPR YSSGGNFETP SKRAPAKGRA GRSKRTEQDH YETDYTTGGE SCDELEEDWI REYPPITSDQ QRQLYKRNFD TGLQEYKSLQ SELDEINKEL SRLDKELDDY REESEEYMAA ADEYNRLKQV KGSADYKSKK NHCKQLKSKL SHIKKMVGDY DRQKT (269-522 aa encoded by BC029886)
Target Information
Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Occludin; phosphatase 1, regulatory subunit 115; tight junction protein occludin
Gene Aliases: AI503564; BLCPMG; Ocl; OCLN; PPP1R115
UniProt ID: (Human) Q16625, (Mouse) Q61146, (Rat) Q6P6T5
Entrez Gene ID: (Pig) 397236, (Human) 100506658, (Mouse) 18260, (Rat) 83497
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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