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Proteintech
OPTN Polyclonal Antibody
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Product Details
10837-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
10837-1-AP recognizes 66 and 70-74 kDa band. The additional 70-74 kDa band is due to phosphorylation.
Immunogen sequence: VSQLLLCLR EGNQKVERLE VALKEAKERV SDFEKKTSNR SEIETQTEGS TEKENDEEKG PETVGSEVEA LNLQVTSLFK ELQEAHTKLS EAELMKKRLQ EKCQALERKN SAIPSELNEK QELVYTNKKL ELQVESMLSE IKMEQAKTED EKSKLTVLQM THNKLLQEHN NALKTIEELT RKESEKVDRA VLKELSEKLE LAEKALASKQ LQMDEMKQTI AKQEEDLETM TILRAQMEVY CSDFHAERAA REKIHEEKEQ LALQLAVLLK ENDAFEDGGR QSLMEMQSRH GARTSDSDQQ AYLVQRGAED RDWRQQRNIP IHSCPKCGEV LPDIDTLQIH VMDCII (233-577 aa encoded by BC013876)
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 14.7K-interacting protein 2; Ag9 C5; E3-14.7K-interacting protein; FIP 2; FIP-2; FIP-2-like protein; HIP 7; HIP-7; Huntingtin interacting protein L; Huntingtin yeast partner L; Huntingtin-interacting protein 7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Optineurin; TFIIIA IntP; TFIIIA-INTP; Transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains; Uban
Gene Aliases: 4930441O07Rik; ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; OPTN; TFIIIA-INTP
UniProt ID: (Human) Q96CV9, (Rat) Q8R5M4, (Mouse) Q8K3K8
Entrez Gene ID: (Human) 10133, (Rat) 246294, (Mouse) 71648
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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