Invitrogen

Nkx2.1 Recombinant Rabbit Monoclonal Antibody (6C11)

View all (85) Nkx2.1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Nkx2.1 Recombinant Rabbit Monoclonal Antibody (6C11)

Product Details

MA5-38304

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6C11

Immunogen

A synthesized peptide derived from human TTF1 (aa 19-32).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

0.02% sodium azide

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898219

Product Specific Information

This antibody has been tested in direct-ELISA

Target Information

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2 homolog A; T/EBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein; TTF-1; TTF1

View more View less

Gene Aliases: BCH; BHC; NK-2; NKX2-1; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1

View more View less

UniProt ID: (Human) P43699

View more View less

Entrez Gene ID: (Human) 7080

View more View less

Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II regulatory region DNA binding core promoter binding intronic transcription regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding enzyme binding transcription regulatory region DNA binding intronic transcription regulatory region DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter neuron migration regulation of blood volume by renin-angiotensin transcription, DNA-templated phospholipid metabolic process axon guidance brain development endoderm development locomotory behavior feeding behavior response to hormone positive regulation of gene expression negative regulation of epithelial to mesenchymal transition globus pallidus development hippocampus development cerebral cortex cell migration forebrain dorsal/ventral pattern formation forebrain neuron fate commitment cerebral cortex GABAergic interneuron differentiation pituitary gland development lung development negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway thyroid gland development forebrain development developmental induction response to lipopolysaccharide Leydig cell differentiation hyperosmotic salinity response positive regulation of circadian rhythm response to ethanol negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter development of primary female sexual characteristics rhythmic process anatomical structure formation involved in morphogenesis oligodendrocyte differentiation lung saccule development epithelial tube branching involved in lung morphogenesis Clara cell differentiation Type II pneumocyte differentiation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support