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Proteintech
NSFL1C Polyclonal Antibody
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Product Details
15620-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MAAERQEAL REFVAVTGAE EDRARFFLES AGWDLQIALA SFYEDGGDED IVTISQATPS SVSRGTAPSD NRVTSFRDLI HDQDEDEEEE EGQRFYAGGS ERSGQQIVGP PRKKSPNELV DDLFKGAKEH GAVAVERVTK SPGETSKPRP FAGGGYRLGA APEEESAYVA GEKRQHSSQD VHVVLKLWKS GFSLDNGELR SYQDPSNAQF LESIRRGEVP AELRRLAHGG QVNLDMEDHR DEDFVKPKGA FKAFTGEGQK LGSTAPQVLS TSSPAQQAEN EAKASSSILI DESEPTTNIQ IRLADGGRLV QKFNHSHRIS DIRLFIVDAR PAMAATSFIL MTTFPNKELA DESQTLKEAN LLNAVIVQRL T (1-370 aa encoded by BC002801)
Target Information
p47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; p97 cofactor p47; RP4-776F14.2; SHP1 homolog; UBX domain-containing protein 2C
Gene Aliases: dJ776F14.1; Munc-18c; NSFL1C; P47; Stxbp3a; UBX1; UBXD10; UBXN2C
UniProt ID: (Human) Q9UNZ2, (Mouse) Q9CZ44
Entrez Gene ID: (Human) 55968, (Mouse) 386649
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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