Invitrogen

NRG1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-27331

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the Intracellular domain of human Neuregulin-1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544807

Product Specific Information

Recommended positive controls: 293T, Mouse brain, Rat brain.

Predicted reactivity: Mouse (91%), Rat (91%), Chicken (84%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1 type III beta 3; NRG-1; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1

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Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297, (Mouse) Q6DR98

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Entrez Gene ID: (Human) 3084, (Rat) 112400, (Mouse) 211323

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Function(s)
transcription cofactor activity protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity cytokine activity ErbB-2 class receptor binding integrin binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor binding protein tyrosine kinase activator activity
Process(es)
MAPK cascade cell morphogenesis cardiac conduction system development ventricular trabecula myocardium morphogenesis transmembrane receptor protein tyrosine kinase signaling pathway activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development heart development muscle organ development locomotory behavior regulation of blood pressure cell proliferation glial cell differentiation negative regulation of cardiac muscle cell apoptotic process glucose transport cell migration glial cell fate commitment cell differentiation positive regulation of cell growth intracellular signal transduction ERBB signaling pathway wound healing negative regulation of protein catabolic process myelination regulation of protein heterodimerization activity cellular protein complex disassembly neurotransmitter receptor metabolic process regulation of cell differentiation positive regulation of cell adhesion positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of Ras protein signal transduction animal organ development neuron fate commitment negative regulation of secretion positive regulation of protein kinase B signaling ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade positive regulation of cardiac muscle cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand activation of MAPK activity startle response cell communication positive regulation of cell proliferation embryo development neural crest cell development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation chemorepulsion involved in interneuron migration from the subpallium to the cortex mammary gland development positive regulation of myelination activation of protein kinase B activity ERBB2 signaling pathway regulation of protein homodimerization activity positive regulation of GTPase activity positive regulation of axon extension positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation positive regulation of dendritic spine development positive regulation of protein targeting to mitochondrion positive regulation of protein localization to cell surface regulation of cell motility negative regulation of neuron migration axon ensheathment
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