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Proteintech

NR2C1 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite NR2C1 Polyclonal Antibody

  • Antibody Testing Data (4)
NR2C1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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NR2C1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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FIGURE: 1 / 4

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NR2C1 Antibody (13658-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer using 13658-1-AP (NR2C1 antibody) at dilution of 1:50 (under 40x lens). Heat mediated antigen retrieved with Citric acid buffer, pH6.0. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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NR2C1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
NR2C1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
NR2C1 Antibody in Western Blot (WB)
NR2C1 Antibody in Western Blot (WB)
NR2C1 Polyclonal Antibody

Product Details

13658-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NR2C1 Fusion Protein Ag4554 (118-467 aa encoded by BC040141)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DKASGRHYG AVTCEGCKGF FKRSIRKNLV YSCRGSKDCI INKHHRNRCQ YCRLQRCIAF GMKQDSVQCE RKPIEVSREK SSNCAASTEK IYIRKDLRSP LTATPTFVTD SESTRSTGLL DSGMFMNIHP SGVKTESAVL MTSDKAESCQ GDLSTLANVV TSLANLGKTK DLSQNSNEMS MIESLSNDDT SLCEFQEMQT NGDVSRAFDT LAKALNPGES TACQSSVAGM EGSVHLITGD SSINYTEKEG PLLSDSHVAF RLTMPSPMPE YLNVHYIGES ASRLLFLSMH WALSIPSFQA LGQENSISLV KAYWNELFTL GLAQCWQVMN VATILATFVN CLHNSLQQAE G (118-467 aa encoded by BC040141)

Target Information

This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 80-3 cNDA; early embryonic nuclear receptor; mTR2; nr2c1; Nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group C isoform; nuclear receptor subfamily 2, group C, member 1; nuclear receptor subfamily 2, group H, member 1; Orphan nuclear receptor TR2; orphan receptor, TR2-11; pregnancy specific beta-1-glycoprotein 4; Testicular receptor 2; TR2 nuclear hormone receptor

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Gene Aliases: 4831444H07Rik; 80.3; Eenr; NR2C1; Psg4; TR2; TR2-11

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UniProt ID: (Human) P13056, (Mouse) Q505F1, (Rat) Q8VIJ4

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Entrez Gene ID: (Human) 7181, (Mouse) 22025, (Rat) 252924

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding steroid hormone receptor activity receptor activity protein binding zinc ion binding protein homodimerization activity histone deacetylase binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter steroid hormone mediated signaling pathway positive regulation of retinoic acid receptor signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter negative regulation of transcription, DNA-templated
It has to be done as per old AB suggested Products section.
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