Osenses

NPY Polyclonal Antibody

Name: NPY Polyclonal Antibody
Brand: Osenses
SKU: OSN00111W-100UL

View all (22) NPY antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (7)

NPY Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

NPY Antibody (OSN00111W-100UL) in IHC (P)

IHC-P on paraffin sections of rat olfactory bulbs. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 mL 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela ... View More

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Immunogen image

Immunogen Image NPY Polyclonal Antibody

Product Details

OSN00111W-100UL

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250-1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

1:500

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 20-60 of mouse NPY conjugated to blue carrier protein was used as the antigen

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The antigen is homologous in many other species including human, rat, zebrafish and xenopus.

Specificity of this antibody: NPY.

Target Information

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase, regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Neuropeptide-Y; OTTHUMP00000201947; prepro-neuropeptide Y; Pro-neuropeptide Y; pro-neuropeptide Y-like

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Gene Aliases: 0710005A05Rik; NPY; NPY02; PYY4; RATNPY; RATNPY02

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UniProt ID: (Human) P01303, (Mouse) P57774, (Rat) P07808

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Entrez Gene ID: (Rat) 100912228, (Human) 4852, (Mouse) 109648, (Rat) 24604

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Function(s)

neuropeptide hormone activity neuropeptide Y receptor binding G-protein coupled receptor binding G-protein coupled receptor activity receptor binding calcium channel regulator activity hormone activity neuropeptide Y receptor activity

Process(es)

neuropeptide signaling pathway cell-cell signaling feeding behavior regulation of blood pressure regulation of appetite chemical synaptic transmission adult feeding behavior central nervous system neuron development cerebral cortex development neuron projection development positive regulation of appetite negative regulation of blood pressure sensory perception of taste calcium ion transport movement of cell or subcellular component G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger digestion behavior blood circulation cell proliferation

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NPY Polyclonal Antibody

NPY Antibody (OSN00111W-100UL) in IHC (P)

Product Details

OSN00111W-100UL

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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