Invitrogen

NMDAR1 Recombinant Rabbit Monoclonal Antibody (1H13L3)

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Datasheet
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Datasheet
Protocols
Questions & Answers
NMDAR1 Recombinant Rabbit Monoclonal Antibody (1H13L3)

Product Details

700685

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100
-

Neutralization (Neu)

-
View 1 publication 1 publication

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

1H13L3

Immunogen

Recombinant protein corresponding to amino acids 834-938 of human NMDA Receptor 1
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532338

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: GluN1; Glun1r; glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1

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Gene Aliases: GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; M100174; MRD8; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID: (Human) Q05586, (Rat) P35439, (Mouse) P35438

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Entrez Gene ID: (Human) 2902, (Rat) 24408, (Mouse) 14810

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Function(s)
NMDA glutamate receptor activity Ras guanyl-nucleotide exchange factor activity extracellular-glutamate-gated ion channel activity calcium channel activity calcium ion binding protein binding calmodulin binding glycine binding glutamate binding enzyme binding voltage-gated cation channel activity glutamate receptor binding neurotransmitter binding protein heterodimerization activity ionotropic glutamate receptor activity receptor binding cation channel activity protein dimerization activity receptor activity ion channel activity
Process(es)
MAPK cascade conditioned taste aversion suckling behavior response to amphetamine cation transport cellular calcium ion homeostasis chemical synaptic transmission respiratory gaseous exchange long-term memory adult locomotory behavior olfactory learning visual learning propylene metabolic process sensory perception of pain pons maturation cerebral cortex development regulation of ion transmembrane transport social behavior ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic regulation of membrane potential positive regulation of apoptotic process response to morphine negative regulation of neuron apoptotic process positive regulation of GTPase activity regulation of respiratory gaseous exchange response to ethanol positive regulation of transcription from RNA polymerase II promoter ephrin receptor signaling pathway regulation of long-term neuronal synaptic plasticity rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis protein tetramerization response to calcium ion regulation of synapse assembly calcium ion homeostasis excitatory postsynaptic potential prepulse inhibition male mating behavior response to fungicide calcium ion transmembrane transport cellular response to manganese ion positive regulation of excitatory postsynaptic potential startle response calcium ion transport learning or memory learning memory associative learning regulation of cell communication positive regulation of cell death response to organic cyclic compound response to amine ion transmembrane transport regulation of neuron apoptotic process regulation of synaptic plasticity regulation of neuronal synaptic plasticity neuromuscular process transport ion transport cation transmembrane transport
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