Bioss

NCX1/SLC8A1 Polyclonal Antibody, Alexa Fluor™ 750

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Datasheet
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Datasheet
Protocols
Questions & Answers
NCX1/SLC8A1 Polyclonal Antibody, Alexa Fluor™ 750

Product Details

BS-1550R-A750

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human NCX1
View immunogen

Conjugate

Alexa Fluor™ 750 Alexa Fluor™ 750 Alexa Fluor™ 750

Excitation/Emission Max

752/776 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; Na-Ca exchanger; Na/Ca exchanger; Sodium/calcium exchanger 1; sodium/calcium exchanger isoform NaCa7; solute carrier family 8 (sodium/calcium exchanger), member 1; Solute carrier family 8 member 1; solute carrier family 8, member 1

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Gene Aliases: AI852629; AV344025; CNC; D930008O12Rik; Ncx; NCX1; SLC8A1

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UniProt ID: (Human) P32418, (Mouse) P70414, (Rat) Q01728

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Entrez Gene ID: (Human) 6546, (Mouse) 20541, (Rat) 29715

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Function(s)
calcium:sodium antiporter activity calcium ion binding protein binding calmodulin binding cytoskeletal protein binding ankyrin binding ion channel binding antiporter activity metal ion binding calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
Process(es)
response to hypoxia embryonic placenta development regulation of the force of heart contraction regulation of heart rate regulation of sodium ion transport heart morphogenesis transport ion transport sodium ion transport calcium ion transport cellular calcium ion homeostasis cellular sodium ion homeostasis cell communication positive regulation of cytosolic calcium ion concentration post-embryonic development positive regulation of fibroblast migration regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion vascular smooth muscle contraction positive regulation of bone mineralization response to ATP cellular response to reactive oxygen species embryonic heart tube development sodium ion transmembrane transport response to muscle stretch relaxation of smooth muscle muscle fiber development negative regulation of cytosolic calcium ion concentration regulation of calcium ion transport cardiac muscle cell development calcium ion homeostasis transmembrane transport cardiac muscle contraction calcium ion transport into cytosol calcium ion import calcium ion transmembrane transport cellular response to caffeine cellular response to cAMP sodium ion export regulation of cardiac muscle cell membrane potential cell communication by electrical coupling involved in cardiac conduction sodium ion import positive regulation of the force of heart contraction calcium ion export response to nutrient response to glucose telencephalon development response to immobilization stress response to drug response to hydrogen peroxide cellular response to hypoxia muscle contraction regulation of cell communication by electrical coupling regulation of cardiac muscle contraction by calcium ion signaling relaxation of cardiac muscle cytosolic calcium ion transport membrane depolarization during cardiac muscle cell action potential regulation of cardiac conduction
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