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Proteintech
Melanophilin Polyclonal Antibody
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Product Details
10338-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: SKLTDEEAQ HVLEVVQRDF DLRRKEEERL EALKGKIKKE SSKRELLSDT AHLNETHCAR CLQPYQLLVN SKRQCLECGL FTCKSCGRVH PEEQGWICDP CHLARVVKIG SLEWYYEHVK ARFKRFGSAK VIRSLHGRLQ GGAGPELISE ERSGDSDQTD EDGEPGSEAQ AQAQPFGSKK KRLLSVHDFD FEGDSDDSTQ PQGHSLHLSS VPEARDSPQS LTDESCSEKA (8-236 aa encoded by BC001653)
Target Information
Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Exophilin-3; leaden; Melanophilin; MGC2771; MGC59733; OTTMUSP00000025451; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a
Gene Aliases: MLPH; SLAC2-A; SLAC2A
UniProt ID: (Human) Q9BV36
Entrez Gene ID: (Human) 79083
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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