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Invitrogen
MUTYH Polyclonal Antibody
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FIGURE: 1 / 6
MUTYH Antibody (PA5-27855) in ICC/IF
Product Details
PA5-27855
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, NIH-3T3.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MYH (mutY homolog (E. coli )) is a DNA glycosylase mismatch repair enzyme that in conjunction with mutM (OGG1), cleaves adenine residues paired with either oxidized (8-hydroxyguanines) or non-modified guanines in order to correct A/G and A/C mismatches. Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair. MYH is crucial for the avoidance of mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation leads to improvements in cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons where mitochondrial genomes exposed to reactive oxygen species (ROS) that damage DNA must maintain integrity over the entire mammalian life span.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase; adenine-DNA glycosylase; hMYH; MGC4416; mMYH; MutY homolog; mutY homolog alpha; mutY-like protein; OTTHUMP00000009098; OTTHUMP00000009102; RP4-534D1.2; the full-length form type A, 5' region
Gene Aliases: 5730495A01Rik; MUTYH; Mutyha; Mutyhalpha; Mutyhb; Mutyhbeta; Mutyhc; MYH
UniProt ID: (Human) Q9UIF7, (Mouse) Q99P21
Entrez Gene ID: (Human) 4595, (Mouse) 70603
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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