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Proteintech
MTA2 Polyclonal Antibody
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Product Details
17554-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MAANMYRVG DYVYFENSSS NPYLVRRIEE LNKTANGNVE AKVVCLFRRR DISSSLNSLA DSNAREFEEE SKQPGVSEQQ RHQLKHRELF LSRQFESLPA THIRGKCSVT LLNETDILSQ YLEKEDCFFY SLVFDPVQKT LLADQGEIRV GCKYQAEIPD RLVEGESDNR NQQKMEMKVW DPDNPLTDRQ IDQFLVVARA VGTFARALDC SSSIRQPSLH MSAAAASRDI TLFHAMDTLQ RNGYDLAKAM STLVPQGGPV LCRDEMEEWS ASEAMLFEEA LEKYGKDFND IRQDFLPWKS LASIVQFYYM WKTTDRYIQQ KRLKAAEADS KLKQVYIPTY TKPNPNQIIS V (1-350 aa encoded by BC053650)
Target Information
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686F2281; metastais-associated gene family, member 2; metastasis -associated gene 1-like 1; metastasis associated 1 family, member 2; metastasis associated 1-like 1; metastasis associated gene family, member 2; Metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; Metastasis-associated protein MTA2; MTA1-L1 protein; p53 target protein in deacetylase complex
Gene Aliases: AW550797; Mata1l1; mmta2; MTA1L1; MTA2; PID
UniProt ID: (Human) O94776, (Mouse) Q9R190
Entrez Gene ID: (Human) 9219, (Rat) 361724, (Mouse) 23942
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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