NeoBiotechnologies

MSH2 Recombinant Mouse Monoclonal Antibody (rMSH2, 6548)

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Datasheet
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Datasheet
Protocols
Questions & Answers
MSH2 Recombinant Mouse Monoclonal Antibody (rMSH2, 6548)

Product Details

4436-MSM10-P1

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Dog, Cat, Human

Host/Isotype

Mouse / IgG2a, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

rMSH2, 6548

Immunogen

Recombinant full-length human MSH2 protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

Target Information

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA mismatch repair protein Msh2; hMSH2; Msh2p; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2; mutS-like protein 2

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Gene Aliases: COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2

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UniProt ID: (Human) P43246

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Entrez Gene ID: (Dog) 494002, (Human) 4436

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Function(s)
magnesium ion binding four-way junction DNA binding Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding DNA binding double-stranded DNA binding single-stranded DNA binding protein binding ATP binding protein C-terminus binding ATPase activity centromeric DNA binding enzyme binding protein kinase binding mismatched DNA binding guanine/thymine mispair binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding protein homodimerization activity ADP binding
Process(es)
meiotic mismatch repair in utero embryonic development oxidative phosphorylation DNA repair mismatch repair postreplication repair double-strand break repair meiotic gene conversion cell cycle arrest reciprocal meiotic recombination germ cell development determination of adult lifespan male gonad development response to X-ray response to UV-B somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments B cell mediated immunity B cell differentiation intra-S DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of neuron apoptotic process maintenance of DNA repeat elements negative regulation of reciprocal meiotic recombination isotype switching negative regulation of DNA recombination positive regulation of helicase activity
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