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Proteintech
MLK3 Polyclonal Antibody
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Product Details
11996-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MEPLKSLFL KSPLGSWNGS GSGGGGGGGG GRPEGSPKAA GYANPVWTAL FDYEPSGQDE LALRKGDRVE VLSRDAAISG DEGWWAGQVG GQVGIFPSNY VSRGGGPPPC EVASFQELRL EEVIGIGGFG KVYRGSWRGE LVAVKAARQD PDEDISVTAE SVRQEARLFA MLAHPNIIAL KAVCLEEPNL CLVMEYAAGG PLSRALAGRR VPPHVLVNWA VQIARGMHYL HCEALVPVIH RDLKSNNILL LQPIESDDME HKTLKITDFG LAREWHKTTQ MSAAGTYAWM APEVIKASTF SKGSDVWSFG VLLWELLTGE VPYRGIDCLA VAYGVAVNKL TLPIPSTCPE PFAQLMADCW AQDPHRRPDF ASILQQLEAL (1-379 aa encoded by BC011263)
Target Information
MAP3K11 (MLK3) is a serine/threonine kinase that activates both the p38 MAP kinase and c-Jun kinase pathways. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP3K11; MGC17114; mitogen activated protein kinase kinase kinase 11; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; Src-homology 3 domain-containing proline-rich kinase
Gene Aliases: 2610017K16Rik; MAP3K11; MEKK11; MLK-3; MLK3; PTK1; RHOE; SPRK
UniProt ID: (Human) Q16584, (Rat) Q66HA1, (Mouse) Q80XI6
Entrez Gene ID: (Human) 4296, (Rat) 309168, (Mouse) 26403
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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