OriGene

MKL1 Monoclonal Antibody (OTI4F6), TrueMAB™

Name: MKL1 Monoclonal Antibody (OTI4F6), TrueMAB\u2122
Brand: OriGene
SKU: TA805132

View all (36) MKL1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)

FIGURE: 1 / 1

MKL1 Antibody (TA805132) in WB

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MKL1 (RC221212, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-MKL1.

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Immunogen image

Immunogen Image MKL1 Monoclonal Antibody (OTI4F6), TrueMAB™

Product Details

TA805132

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI4F6

Immunogen

Human recombinant protein fragment corresponding to amino acids 165-397 of human MKL1 produced in E.coli.

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: basic, SAP and coiled-coil domain; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; mixed lineage leukemia; MKL/myocardin-like protein 1; MRTF-A; Myocardin-related transcription factor A

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Gene Aliases: BSAC; KIAA1438; MAL; MKL1; MRTF-A; MRTFA

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UniProt ID: (Human) Q969V6

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Entrez Gene ID: (Human) 57591

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Function(s)

transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription coactivator activity transcription factor activity, sequence-specific DNA binding transcription coactivator activity actin binding actin monomer binding protein binding leucine zipper domain binding

Process(es)

transcription, DNA-templated positive regulation of transcription via serum response element binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation negative regulation of apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MKL1 Monoclonal Antibody (OTI4F6), TrueMAB™

MKL1 Antibody (TA805132) in WB

Product Details

TA805132

Western Blot (WB)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

References (0)

Bioinformatics

Performance Guarantee

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