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Invitrogen
MBD2 Recombinant Rabbit Monoclonal Antibody (JE57-73)
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FIGURE: 1 / 5
MBD2 Antibody (MA5-42520) in IHC (P)
Product Details
MA5-42520
Species Reactivity
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Product Specific Information
Positive Control: Raji cell lysates, rat kidney tissue, human lung carcinoma tissue, human breast carcinoma tissue, Daudi.
Subcellular Location: Nucleus.
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Demethylase; DKFZp586O0821; DMTase; Methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2
Gene Aliases: DMTase; MBD2; MBD2a; NY-CO-41
UniProt ID: (Human) Q9UBB5, (Mouse) Q9Z2E1
Entrez Gene ID: (Human) 8932, (Rat) 680172, (Mouse) 17191
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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