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Invitrogen
MB67 Polyclonal Antibody
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Product Details
PA5-120678
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
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Shipping conditions
RRID
Product Specific Information
Positive test controls include: HT-29, Mouse liver, Rat liver. The target is usually found in the following locations: Cytoplasm, Nucleus, cytoskeleton.
Immunogen sequence: PVQLSKEQEE LIRTLLGAHT RHMGTMFEQF VQFRPPAHLF IHHQPLPTLA PVLPLVTHFA DINTFMVLQV IKFTKDLPVF RSLPIEDQIS LLKGAAVEIC HIVLNTTFCL QTQNFLCGPL RYTIEDGARV SPTVGFQVEF LELLFHFHGT LRKLQLQEPE YVLLAAMALF SPDRPGVTQR DEIDQLQEEM ALTLQSYIKG QQRRPRDRFL YAKLLGLLAE LRSINEAYGY QIQHIQGLSA MMPLLQEICS
Target Information
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CAR; Constitutive activator of retinoid response; constitutive active receptor; Constitutive active response; constitutive androstane nuclear receptor variant 2; constitutive androstane nuclear receptor variant 3; constitutive androstane nuclear receptor variant 4; constitutive androstane nuclear receptor variant 5; Constitutive androstane receptor; constitutively transactivates RAREs; MGC150433; MGC97144; MGC97209; nuclear receptor constitutive active receptor; Nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; Orphan nuclear receptor MB67; strain Fischer nuclear receptor (CAR)
Gene Aliases: AA209988; AI551208; CAR; CAR-beta; CAR1; Care2; ESTM32; MB67; NR1I3
UniProt ID: (Human) Q14994, (Mouse) O35627, (Rat) Q9QUS1
Entrez Gene ID: (Human) 9970, (Mouse) 12355, (Rat) 65035
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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