Fabgennix

MAPK3 Polyclonal Antibody, FITC

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Datasheet
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Datasheet
Protocols
Questions & Answers
MAPK3 Polyclonal Antibody, FITC

Product Details

MAPK3-Y-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 300-350 on human Mitogen-activated protein kinase 3.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

MAPK3 (ERK1) is a serine/threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. Functionally, ERK1 is involved with a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. ERK1 is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms of ERK1 have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ERK; ERK-1; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAP kinase2; MAPK 1; MAPK 3; MAPK2; Microtubule-associated protein 2 kinase; mitogen-activated 3; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MNK1; p44 MAP kinase; p44-ERK1; p44-MAPK; pp42/MAP kinase

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Gene Aliases: ERK-1; ERK1; ERT2; Esrk1; HS44KDAP; HUMKER1A; MAPK1; MAPK3; MNK1; Mtap2k; p44; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3

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UniProt ID: (Human) P27361, (Rat) P21708, (Mouse) Q63844

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Entrez Gene ID: (Human) 5595, (Rat) 50689, (Mouse) 26417

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Function(s)
phosphotyrosine binding protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding kinase activity phosphatase binding scaffold protein binding protein kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
MAPK cascade MAPK import into nucleus positive regulation of protein phosphorylation transcription, DNA-templated protein complex assembly protein phosphorylation apoptotic process cellular response to DNA damage stimulus DNA damage induced protein phosphorylation response to toxic substance organ morphogenesis phosphorylation peptidyl-serine phosphorylation sensory perception of pain arachidonic acid metabolic process BMP signaling pathway lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide regulation of stress-activated MAPK cascade positive regulation of histone phosphorylation positive regulation of histone acetylation intracellular signal transduction peptidyl-tyrosine autophosphorylation response to exogenous dsRNA positive regulation of translation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of sequence-specific DNA binding transcription factor activity cartilage development regulation of cytoskeleton organization lung morphogenesis trachea formation positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway response to epidermal growth factor cellular response to mechanical stimulus caveolin-mediated endocytosis regulation of Golgi inheritance regulation of early endosome to late endosome transport negative regulation of apolipoprotein binding activation of MAPK activity transcription initiation from RNA polymerase I promoter cell cycle axon guidance fibroblast growth factor receptor signaling pathway regulation of phosphatidylinositol 3-kinase signaling viral process platelet activation thyroid gland development positive regulation of cyclase activity positive regulation of telomere maintenance via telomerase Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis outer ear morphogenesis thymus development positive regulation of telomerase activity Bergmann glial cell differentiation face development JAK-STAT cascade involved in growth hormone signaling pathway cardiac neural crest cell development involved in heart development ERK1 and ERK2 cascade regulation of cellular response to heat positive regulation of telomere capping positive regulation of xenophagy signal transduction
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