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Fabgennix
LIM kinase 2 Polyclonal Antibody, FITC
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Product Details
LIMK2-Y-FITC
Species Reactivity
Host/Isotype
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Type
Immunogen
Conjugate
Excitation/Emission Max
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Target Information
LIMK2 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK2 has also been implicated in brain development. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for LIMK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: EC 2.7.11.1; kinase LIMK2; LIM domain kinase 2; LIM kinase 2; LIM motif-containing protein kinase 2; LIMK; LIMK 2; LIMK-1; LIMK-2; LIMK1; LINhp-2; OTTHUMP00000199483
Gene Aliases: Limk-2; LIMK2; Limk2b; Link2
UniProt ID: (Human) P53671, (Mouse) O54785, (Rat) P53670
Entrez Gene ID: (Human) 3985, (Mouse) 16886, (Rat) 29524
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