Invitrogen

LHR Polyclonal Antibody

1 Published Figure
1 Reference
View all (25) LHR antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
LHR Polyclonal Antibody

Product Details

PA5-97923

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human Lutropin-choriogonadotropic hormone receptor protein (27-363AA)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2812537

Target Information

LHCGR encodes the receptor for both luteinizing hormone and choriogonadotropin. It is family 1 of G-protein coupled receptors, FSH/LSH/TSH superfamily, and its basic function is acting as luteinizing hormone/choriogonadotropin receptor (gonadotropin receptor). Regulating the development and function of Leyding cells in males. It also plays a role in male secondary sexual characterdevelopment. Mutations in this gonadotropinreceptor results in disorders of male secondary sexual characteristic development, such as familial male precocious puperty and male pseudohermaphtoditism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HCG receptor; hypergonadotropic hypogonadism; LH/CG-R; LHR; LSH-R; Luteinizing hormone receptor; Lutropin receptor; Lutropin-choriogonadotropic hormone receptor; lutropin/choriogonadotropin receptor

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Gene Aliases: Gpcr19-rs1; HHG; LCGR; LGR2; LH-R; LH/CG-R; LH/CGR; LHCGR; LHR; LHRHR; LSH-R; ULG5

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UniProt ID: (Human) P22888, (Mouse) P30730

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Entrez Gene ID: (Human) 3973, (Mouse) 16867

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Function(s)
luteinizing hormone receptor activity G-protein coupled peptide receptor activity choriogonadotropin hormone receptor activity choriogonadotropin hormone binding signal transducer activity G-protein coupled receptor activity protein-hormone receptor activity peptide hormone binding identical protein binding protein homodimerization activity ATPase binding
Process(es)
G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway male gonad development hormone-mediated signaling pathway ovulation cycle process male genitalia development positive regulation of inositol trisphosphate biosynthetic process luteinizing hormone signaling pathway positive regulation of cAMP-mediated signaling cognition cellular response to gonadotropin stimulus ovarian follicle development protein targeting to lysosome signal transduction adenylate cyclase-modulating G-protein coupled receptor signaling pathway spermatogenesis female gonad development positive regulation of calcium ion transport into cytosol development of secondary male sexual characteristics positive regulation of hormone biosynthetic process arachidonic acid secretion positive regulation of calcium-mediated signaling positive regulation of release of sequestered calcium ion into cytosol uterus development seminiferous tubule development regulation of steroid hormone biosynthetic process
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