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Invitrogen
LGMN Recombinant Rabbit Monoclonal Antibody (23GB2095)
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FIGURE: 1 / 2
LGMN Antibody (MA5-54040) in WB
Product Details
MA5-54040
Species Reactivity
Host/Isotype
Expression System
Class
Type
Clone
Immunogen
Conjugate
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Purification
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RRID
Target Information
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: AEP; Asparaginyl endopeptidase; cysteine protease 1; Legumain; preprolegumain; Protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1EC 3.4.22.34
Gene Aliases: AEP; AI746452; AU022324; LGMN; LGMN1; PRSC1
UniProt ID: (Human) Q99538, (Mouse) O89017, (Rat) Q9R0J8
Entrez Gene ID: (Human) 5641, (Mouse) 19141, (Rat) 63865
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