Invitrogen

KIF14 Polyclonal Antibody

View all (13) KIF14 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
KIF14 Polyclonal Antibody

Product Details

PA5-87769

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1399-1648 of human KIF14 (NP_0556901)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.46 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804396

Product Specific Information

Immunogen sequence: LENGNNKAAS VQEEFMDAVC DGVGLGMKIL LDSGLEKAKE LQHELFRQCT KNEVTKEMKT NAMGLIRSLE NIFAESKIKS FRRQVQEENF EYQDFKRMVN RAPEFLKLKH CLEKAIEIII SALKGCHSDI NLLQTCVESI RNLASDFYSD FSVPSTSVGS YESRVTHIVH QELESLAKSL LFCFESEESP DLLKPWETYN QNTKEEHQQS KSSGIDGSKN KGVPKRVYEL HGSSPAVSSE ECTPSRIQWV; Positive Samples: HeLa, HL-60; Cellular Location: Cytoplasm, Midbody, Nucleus, cytoskeleton, spindle

Target Information

This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Kinesin-like protein KIF14; N-3 kinesin; truncated kinesin family member 14

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Gene Aliases: D1Ertd367e; E130203M01; KIAA0042; KIF14; MKS12

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UniProt ID: (Human) Q15058, (Mouse) L0N7N1

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Entrez Gene ID: (Human) 9928, (Mouse) 381293, (Rat) 360849

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Function(s)
microtubule motor activity protein binding ATP binding microtubule binding ATP-dependent microtubule motor activity, plus-end-directed tubulin binding ATPase activity protein kinase binding PDZ domain binding nucleotide binding
Process(es)
regulation of cell growth microtubule-based movement microtubule depolymerization mitotic metaphase plate congression positive regulation of cell proliferation regulation of G2/M transition of mitotic cell cycle cerebellar granular layer structural organization cerebellar Purkinje cell layer structural organization cerebellar cortex development hippocampus development olfactory bulb development cell proliferation in forebrain cerebral cortex development regulation of cell adhesion regulation of cell migration cytoskeleton-dependent intracellular transport SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of myelination activation of protein kinase activity positive regulation of cytokinesis regulation of Rap protein signal transduction negative regulation of integrin activation substrate adhesion-dependent cell spreading negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process establishment of protein localization cell division mitotic cell cycle process regulation of cell maturation regulation of G1/S transition of mitotic cell cycle response to docetaxel trihydrate metabolic process
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