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OriGene

JAG1 Monoclonal Antibody (OTI3A10), TrueMAB™

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Questions & Answers

Cite JAG1 Monoclonal Antibody (OTI3A10), TrueMAB™

  • Antibody Testing Data (8)
JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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JAG1 Antibody (CF807944) in IHC (P)

Immunohistochemical staining of paraffin-embedded human lymph node tissue within the normal limits using anti-JAG1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807944)(1:150 {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
JAG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
JAG1 Antibody in Western Blot (WB)
JAG1 Monoclonal Antibody (OTI3A10), TrueMAB™

Product Details

CF807944

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI3A10

Immunogen

Human recombinant protein fragment corresponding to amino acids 523-759 of human JAG1 produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1

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Gene Aliases: AGS; AHD; AWS; CD339; HJ1; JAG1; JAGL1

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UniProt ID: (Human) P78504

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Entrez Gene ID: (Human) 182

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Function(s)
Notch binding structural molecule activity calcium ion binding protein binding growth factor activity
Process(es)
angiogenesis cell fate determination blood vessel remodeling morphogenesis of an epithelial sheet T cell mediated immunity pulmonary valve morphogenesis cardiac right ventricle morphogenesis Notch signaling pathway Notch receptor processing nervous system development hemopoiesis keratinocyte differentiation regulation of cell migration response to muramyl dipeptide aorta morphogenesis regulation of cell proliferation auditory receptor cell differentiation myoblast differentiation endothelial cell differentiation negative regulation of fat cell differentiation positive regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter cardiac septum morphogenesis ciliary body morphogenesis pulmonary artery morphogenesis cardiac neural crest cell development involved in outflow tract morphogenesis Notch signaling involved in heart development endocardial cushion cell development nephron development glomerular visceral epithelial cell development distal tubule development loop of Henle development neuronal stem cell population maintenance negative regulation of stem cell differentiation
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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