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Proteintech
Iduronate 2 sulfatase Monoclonal Antibody (1A3F9)
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Product Details
66112-1-IG
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Product Specific Information
Immunogen sequence: MPPPRTGRG LLWLGLVLSS VCVALGSETQ ANSTTDALNV LLIIVDDLRP SLGCYGDKLV RSPNIDQLAS HSLLFQNAFA QQAVCAPSRV SFLTGRRPDT TRLYDFNSYW RVHAGNFSTI PQYFKENGYV TMSVGKVFHP GISSNHTDDS PYSWSFPPYH PSSEKYENTK TCRGPDGELH ANLLCPVDVL DVPEGTLPDK QSTEQAIQLL EKMKTSASPF FLAVGYHKPH IPFRYPKEFQ KLYPLENITL APDPEVPDGL PPVAYNPWMD IRQREDVQAL NISVPYGPIP VDFQEDQSST GFRLKTSSTR KYK (1-312 aa encoded by BC006170)
Target Information
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Alpha-L-iduronate sulfate sulfatase; Iduronate 2-sulfatase; iduronate 2-sulfatase 14 kDa chain; iduronate 2-sulfatase 42 kDa chain; iduronate sulfatase; iduronate-2-sulfatase; Idursulfase
Gene Aliases: AW214631; IDS; MPS2; SIDS
UniProt ID: (Human) P22304, (Mouse) Q08890
Entrez Gene ID: (Human) 3423, (Mouse) 15931, (Rat) 363513
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