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Invitrogen
IRAK4 Polyclonal Antibody
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FIGURE: 1 / 9
IRAK4 Antibody (PA5-20018) in ICC/IF
Product Details
PA5-20018
Species Reactivity
Published species
Host/Isotype
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Immunogen
Conjugate
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Product Specific Information
In Western blot applications, this antibody detects a band at ~50kDa. A suggested positive control is K562 cell lysate.
PA5-20018 can be used with blocking peptide PEP-0137.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: interleukin-1; Interleukin-1 receptor-associated kinase 4; IRAK-4; Renal carcinoma antigen NY-REN-64
Gene Aliases: IPD1; IRAK-4; IRAK4; NY-REN-64; REN64
UniProt ID: (Human) Q9NWZ3
Entrez Gene ID: (Human) 51135
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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