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Proteintech
INTS3 Polyclonal Antibody
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Product Details
16620-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: YHLLYYLRA SKAAAGKMNL YESFAQATQL GDLHTCLMMD MKACQEDDVR LLCHLTPSIY TEFPDETLRS GELLNMIVAV IDSAQLQELV CHVMMGNLVM FRKDSVLNIL IQSLDWETFE QYCAWQLFLA HNIPLETIIP ILQHLKYKEH PEALSCLLLQ LRREKPSEEM VKMVLSRPCH PDDQFTTSIL RHWCMKHDEL LAEHIKSLLI KNNSLPRKRQ SLRSSSSKLA QLTLEQILEH LDNLRLNLTN TKQNFFSQTP ILQALQHVQA SCDEAHKMKF SDLFSLAEEY EDSSTKPPKS RRKAALSSPR SRKNATQPPN AEEESGSSSA SEEEDTKPKP TKRKRKGSSA VGSDSD (91-445 aa encoded by BC025254)
Target Information
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Int3; Integrator complex subunit 3; Sensor of single-strand DNA complex subunit A; sensor of ssDNA subunit A; SOSS complex subunit A; SOSS-A
Gene Aliases: C1orf193; C1orf60; C77668; INT3; INTS3; RGD1304593; SOSS-A; SOSSA
UniProt ID: (Human) Q68E01, (Mouse) Q7TPD0
Entrez Gene ID: (Human) 65123, (Mouse) 229543, (Rat) 361988
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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