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  • Primary Antibodies ›
  • IL18RAP Antibodies

Invitrogen

IL18RAP Polyclonal Antibody

View all (21) IL18RAP antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite IL18RAP Polyclonal Antibody

  • Antibody Testing Data (1)
IL18RAP Antibody in Neutralization (Neu)
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IL18RAP Antibody in Neutralization (Neu)
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IL18RAP Antibody (PA5-47087) in Neu

Neutralization of IL18RAP in KG‚1 human acute myelogenous leukemia cell line. Samples were incubated in IL18RAP polyclonal antibody (Product # PA5-47087). In the presence of Recombinant Human TNF‚α (20 ng/mL), Recombinant Human IL‚18/IL‚1F4 stimulates IFN‚γ secretion in the KG‚1 human acute myelogenous leukemia cell line in a dose-dependent manner (orange line), as measured by the Human IFN‚γ Quantikine ELISA Kit. Under these conditions, IFN‚γ secretion elicited by Recombinant Human IL‚18/IL‚1F4 (40 ng/mL) is neutralized (green line) by in... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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IL18RAP Antibody in Neutralization (Neu)
IL18RAP Polyclonal Antibody

Product Details

PA5-47087

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1 µg/mL
-

Neutralization (Neu)

0.3-1.2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant human IL-18 R beta/IL-1 R7 Phe20-Arg356
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609928

Product Specific Information

In direct ELISAs, less than 1% cross-reactivity with recombinant mouse IL-18 R beta (AcPL), recombinant human (rh) IL-18 R, rhIL-1 R1, rhIL-1 RII, and rhIL-1 Rrp2 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Accessory protein-like; AcPL; CD218 antigen-like family member B; CD218b; CDw218b; cluster of differentiation w218b; IL-18 RA; IL-18 receptor accessory protein; IL-18 receptor beta; IL-18R-beta; IL-1R accessory protein-like; IL-1R-7; IL-1RAcPL; Interleukin-1 receptor 7; Interleukin-18 receptor accessory protein; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta

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Gene Aliases: ACPL; CD218b; CDw218b; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RAP; IL18RB; IL1R7

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UniProt ID: (Human) O95256

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Entrez Gene ID: (Human) 8807

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Function(s)
receptor activity
Process(es)
inflammatory response immune response cell surface receptor signaling pathway cellular response to hydrogen peroxide cellular response to cytokine stimulus
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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