Proteintech

IL1 beta Polyclonal Antibody

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View all (119) IL-1 beta antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
IL1 beta Polyclonal Antibody

Product Details

16806-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:1,000
View 402 publications 402 publications

Immunohistochemistry (IHC)

-
View 78 publications 78 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:20-1:200
View 29 publications 29 publications

ELISA (ELISA)

-
View 4 publications 4 publications

Miscellaneous PubMed (MISC)

-
View 2 publications 2 publications

Not applicable (N/A)

-
View 10 publications 10 publications
Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IL1 beta Fusion Protein Ag10295 (1-269 aa encoded by BC008678)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEVPELAS EMMAYYSGNE DDLFFEADGP KQMKCSFQDL DLCPLDGGIQ LRISDHHYSK GFRQAASVVV AMDKLRKMLV PCPQTFQEND LSTFFPFIFE EEPIFFDTWD NEAYVHDAPV RSLNCTLRDS QQKSLVMSGP YELKALHLQG QDMEQQVVFS MSFVQGEESN DKIPVALGLK EKNLYLSCVL KDDKPTLQLE SVDPKNYPKK KMEKRFVFNK IEINNKLEFE SAQFPNWYIS TSQAENMPVF LGGTKGGQDI TDFTMQFVSS (1-269 aa encoded by BC008678)

Target Information

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Catabolin; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1β; IL-1 beta; IL1 B; IL1β; ILN; Interleukin; Interleukin 1 beta precursor; interleukin 1, beta; Interleukin-1 beta; Interleukin-1b; Interleukin1 beta; LAF; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; pro-interleukin-1-beta

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Gene Aliases: IL-1; IL1-BETA; IL1B; IL1F2

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UniProt ID: (Human) P01584

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Entrez Gene ID: (Human) 3553

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Function(s)
cytokine activity interleukin-1 receptor binding protein domain specific binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPK activity fever generation response to hypoxia positive regulation of protein phosphorylation chronic inflammatory response to antigenic stimulus positive regulation of T cell mediated immunity purine nucleobase metabolic process apoptotic process inflammatory response signal transduction positive regulation of cytosolic calcium ion concentration cell-cell signaling embryo implantation aging memory estrogen metabolic process negative regulation of cell proliferation glycoprotein metabolic process response to heat response to ozone response to gamma radiation positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of glucose transport negative regulation of glutamate secretion smooth muscle adaptation cytokine-mediated signaling pathway pentacyclic triterpenoid metabolic process hyaluronan biosynthetic process neutrophil chemotaxis polyketide metabolic process ovulation sequestering of triglyceride positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of fever generation lipopolysaccharide-mediated signaling pathway positive regulation of prostaglandin secretion response to estradiol interleukin-1 beta production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of immature T cell proliferation in thymus positive regulation of histone phosphorylation response to ATP response to vitamin D response to L-ascorbic acid positive regulation of heterotypic cell-cell adhesion positive regulation of histone acetylation social behavior ectopic germ cell programmed cell death positive regulation of myosin light chain kinase activity response to stilbenoid cellular response to drug response to diuretic response to statin wound healing positive regulation of T cell proliferation positive regulation of NF-kappaB import into nucleus positive regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling response to morphine negative regulation of MAP kinase activity response to peptide hormone protein kinase B signaling positive regulation of JUN kinase activity positive regulation of chemokine biosynthetic process positive regulation of interleukin-2 biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process response to ethanol negative regulation of neuron differentiation positive regulation of angiogenesis negative regulation of lipid metabolic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade negative regulation of insulin receptor signaling pathway positive regulation of protein export from nucleus positive regulation of astrocyte differentiation positive regulation of phagocytosis regulation of insulin secretion negative regulation of lipid catabolic process positive regulation of lipid catabolic process regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of cell division positive regulation of cell adhesion molecule production positive regulation of calcidiol 1-monooxygenase activity negative regulation of adiponectin secretion positive regulation of ERK1 and ERK2 cascade monocyte aggregation cellular response to antibiotic cellular response to mechanical stimulus cellular response to organic substance cellular response to glucose stimulus cellular response to fatty acid cellular response to organic cyclic compound cellular response to methotrexate response to dexamethasone positive regulation of monocyte chemotactic protein-1 production positive regulation of neutrophil chemotaxis extrinsic apoptotic signaling pathway in absence of ligand regulation of establishment of endothelial barrier negative regulation of branching morphogenesis of a nerve negative regulation of neural precursor cell proliferation positive regulation of interleukin-6 secretion negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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