Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
IGF2R Monoclonal Antibody (2G11)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 21
IGF2R Antibody (MA1-066) in ICC/IF
Product Details
MA1-066
Species Reactivity
Published species
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
MA1-066 detects mannose 6-phospate receptor (MPR) from human, rat, monkey and bovine tissues. This antibody does not detect Chinese hamster ovary cell MPR.
MA1-066 has been successfully used in Western blot, immunofluorescence, EM immunocytochemistry and immunoprecipitation procedures. By Western blot, this antibody detects a ~300 kDa protein representing MPR in HeLa cell extract under non-reducing conditions. Immunofluorescence staining of MPR in HeLa cells with MA1-066 results in perinuclear staining.
MA1-066 immunogen is purified bovine ~300 kDa Cl-MPR. This antibody is shown to recognize an epitope in the extracellular domain of MPR.
Target Information
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of approximately 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and approximately 10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An approximately 240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 300 kDa mannose 6-phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; IGF-II receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; insulin-like growth factor receptor type 2; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300
Gene Aliases: BOS_9999; CD222; CI-M6PR; CI-MPR; CIMPR; IGF2R; Igfr2; M6P; M6P-R; M6P/IGF2R; MPR 300; MPR1; MPR300; MPRI
UniProt ID: (Human) Q7Z7G9, (Bovine) P08169
Entrez Gene ID: (Human) 3482, (Bovine) 281849, (Rat) 25151
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support