Invitrogen

ID2 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
ID2 Polyclonal Antibody

Product Details

PA5-79434

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ID2 (86-120aa VSLHHQRPGQNQASRTPLTTLNTDISILSLQASEF).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746550

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat brain tissue.

Target Information

The inhibitor of DNA binding 2 (ID2) protein is essential for promoting the development of a number of cell types including natural killer cell, erythroid precursors, as well as, CD8+ and CD4+ T-cell. A lack of ID2 promotes B-cell development. The chief role of this protein is to associate with ubiquitously-expressed E proteins, and other proteins of the basic helix-loop-helix (HLH) family, preventing them from binding to DNA and activating transcription. Activation of ID2 is critical for the development of the natural killer cell lineage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHb26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; helix-loop-helix protein ID2; Inhibitor of differentiation 2; Inhibitor of DNA binding 2; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389; OTTHUMP00000140258; OTTHUMP00000200297

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Gene Aliases: Ac2-300; BHLHB26; GIG8; Id-2; ID2; ID2A; ID2H

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UniProt ID: (Human) Q02363, (Rat) P41137

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Entrez Gene ID: (Human) 3398, (Rat) 25587

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Function(s)
protein binding ion channel binding protein dimerization activity protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter metanephros development natural killer cell differentiation leukocyte differentiation membranous septum morphogenesis bundle of His development transcription, DNA-templated heart development positive regulation of cell proliferation entrainment of circadian clock positive regulation of gene expression negative regulation of gene expression oligodendrocyte development regulation of lipid metabolic process olfactory bulb development neuron differentiation circadian regulation of gene expression mammary gland epithelial cell proliferation regulation of circadian rhythm entrainment of circadian clock by photoperiod enucleate erythrocyte differentiation negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity locomotor rhythm negative regulation of B cell differentiation positive regulation of fat cell differentiation positive regulation of erythrocyte differentiation positive regulation of macrophage differentiation negative regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of blood pressure positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated cell development cell maturation Peyer's patch development embryonic digestive tract morphogenesis positive regulation of smooth muscle cell proliferation neuron fate commitment positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation adipose tissue development mammary gland alveolus development epithelial cell differentiation involved in mammary gland alveolus development endodermal digestive tract morphogenesis positive regulation of cell cycle arrest cellular response to lithium ion cellular senescence regulation of G1/S transition of mitotic cell cycle negative regulation of neural precursor cell proliferation thigmotaxis multicellular organism development adult locomotory behavior cell morphogenesis involved in neuron differentiation positive regulation of transcription involved in G1/S transition of mitotic cell cycle
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