Invitrogen

HTR2A Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
HTR2A Polyclonal Antibody

Product Details

PA5-120747

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HTR2A (NP_000612.1).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914319

Product Specific Information

Positive test controls include: SH-SY5Y, Mouse brain.

Immunogen sequence: MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS

Target Information

In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5-HT-2; 5-HT-2A; 5-HT2 receptor; 5-HT2A receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; serotonin 5-HT-2A receptor; Serotonin receptor 2A; SR2A

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Gene Aliases: 5-HT2A; E030013E04; Htr-2; HTR2; HTR2A

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UniProt ID: (Human) P28223, (Mouse) P35363

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Entrez Gene ID: (Human) 3356, (Mouse) 15558

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Function(s)
virus receptor activity G-protein alpha-subunit binding G-protein coupled serotonin receptor activity drug binding protein complex binding serotonin binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding signal transducer activity G-protein coupled receptor activity
Process(es)
temperature homeostasis cellular calcium ion homeostasis smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway activation of phospholipase C activity positive regulation of cytosolic calcium ion concentration phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway behavior memory cell death positive regulation of cell proliferation positive regulation of phosphatidylinositol biosynthetic process regulation of dopamine secretion phosphatidylinositol 3-kinase signaling artery smooth muscle contraction urinary bladder smooth muscle contraction sensory perception of pain sleep positive regulation of kinase activity response to drug negative regulation of potassium ion transport positive regulation of MAP kinase activity protein localization to cytoskeleton positive regulation of fat cell differentiation positive regulation of glycolytic process positive regulation of vasoconstriction regulation of hormone secretion behavioral response to cocaine positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain release of sequestered calcium ion into cytosol negative regulation of synaptic transmission, glutamatergic positive regulation of ERK1 and ERK2 cascade chemical synaptic transmission aging viral entry into host cell
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