Invitrogen

HSP60 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
HSP60 Polyclonal Antibody

Product Details

PA5-79414

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human Hsp60 recombinant protein (Position: A260-Q496).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746530

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Hela whole cell, human A549 whole cell, human PANC-1 whole cell, human MCF-7 whole cell, rat liver tissue, mouse liver tissue, mouse thymus tissue. IHC: Mouse Intestine Tissue, Rat Intestine Tissue, Human Intestinal Cancer Tissue. ICC/IF: U20S cell, SMMC-7721 cell.

Target Information

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 60 kDa chaperonin; 60 kDa heat shock protein; 60 kDa heat shock protein, mitochondrial; Chaperonin 60; CPN60; heat shock 60kD protein 1 (chaperonin); heat shock 60kDa protein 1; heat shock 60kDa protein 1 (chaperonin); Heat shock protein; Heat shock protein 60; heat shock protein 60 (liver); heat shock protein 65; Heat shock protein family D member 1; heat shock protein, 60 kDa; HSP; HSP-60; HSP-65; Hsp60s1; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; short heat shock protein 60 Hsp60s1

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Gene Aliases: 60kDa; CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HSPD1; Hspd1-30p; HuCHA60; SPG13

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UniProt ID: (Human) P10809, (Mouse) P63038, (Rat) P63039

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Entrez Gene ID: (Human) 3329, (Mouse) 15510, (Rat) 63868

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Function(s)
lipopolysaccharide binding p53 binding DNA replication origin binding single-stranded DNA binding double-stranded RNA binding protein binding ATP binding ATPase activity ubiquitin protein ligase binding poly(A) RNA binding unfolded protein binding chaperone binding nucleotide binding protease binding protein complex binding insulin binding protein heterodimerization activity misfolded protein binding
Process(es)
detection of misfolded protein B cell cytokine production MyD88-dependent toll-like receptor signaling pathway positive regulation of T cell mediated immune response to tumor cell protein folding activation of cysteine-type endopeptidase activity involved in apoptotic process response to unfolded protein positive regulation of interferon-alpha production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production protein refolding B cell proliferation T cell activation B cell activation positive regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process isotype switching to IgG isotypes positive regulation of inflammatory response protein stabilization positive regulation of T cell activation chaperone mediated protein folding requiring cofactor 'de novo' protein folding response to cold viral process chaperone-mediated protein complex assembly protein maturation response to hypoxia response to heat response to organic substance response to organic cyclic compound response to lipopolysaccharide response to ATP response to cocaine response to drug response to hydrogen peroxide response to estrogen
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