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Invitrogen
HP1 alpha Monoclonal Antibody
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FIGURE: 1 / 4
HP1 alpha Antibody (MA1-218) in ICC/IF
Product Details
MA1-218
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Purification
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Product Specific Information
MA1-218 detects CBX5 from human and non-human primate samples. CBX5 has an approximate molecular weight of 22.2kDa.
MA1-218 has been successfully used in Western blot, immunofluorescence,and immunohistochemistry applications.
The MA1-218 Immunogen is the purified recombinant fragment of human CBX5 (AA: 1-191) expressed in E. Coli.
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Antigen p25; Cbx5 antibody; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; epididymis luminal protein 25; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP-1 alpha antibody; HP1 alpha; HP1 alpha homolog; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha
Gene Aliases: CBX5; HEL25; HP1; HP1A
UniProt ID: (Human) P45973
Entrez Gene ID: (Human) 23468
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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