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Proteintech
HKDC1 Polyclonal Antibody
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Product Details
25874-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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Product Specific Information
Immunogen sequence: MFAVHLMAF YFSKLKEDQI KKVDRFLYHM RLSDDTLLDI MRRFRAEMEK GLAKDTNPTA AVKMLPTFVR AIPDGSENGE FLSLDLGGSK FRVLKVQVAE EGKRHVQMES QFYPTPNEII RGNGTELFEY VADCLADFMK TKDLKHKKLP LGLTFSFPCR QTKLEEGVLL SWTKKFKARG VQDTDVVSRL TKAMRRHKDM DVDILALVND T (1-210 aa encoded by BC110504)
Target Information
The epidermal growth factor receptor (HKDC1; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: HKDC1 (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). HKDC1 exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). HKDC1 and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to HKDC1 overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of HKDC1, called HKDC1vIII is often observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Hexokinase domain-containing protein 1; Hexokinase HKDC1; putative hexokinase HKDC1
Gene Aliases: BC016235; HKDC1
UniProt ID: (Human) Q2TB90, (Mouse) Q91W97
Entrez Gene ID: (Human) 80201, (Mouse) 216019
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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