Bioss

HFE/Hemochromatosis Polyclonal Antibody

View all (16) HFE antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
HFE/Hemochromatosis Polyclonal Antibody

Product Details

BS-12335R

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human HFE/Hemochromatosis, amino acids 262-348.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin. It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Hereditary hemochromatosis protein; hereditary hemochromatosis protein HLA-H; Hereditary hemochromatosis protein homolog; HFE 1; high Fe; HLA H; HLA-H; MGC10379; MGC103790; MGC:150812; MHC class I-like protein HFE; RT1-CAFE

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Gene Aliases: HFE; HFE1; HH; HLA-H; HLAH; MR2; MVCD7; TFQTL2

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UniProt ID: (Human) Q30201, (Rat) O35799, (Mouse) P70387

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Entrez Gene ID: (Human) 3077, (Rat) 29199, (Mouse) 15216

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Function(s)
antigen binding receptor binding protein binding beta-2-microglobulin binding co-receptor binding peptide antigen binding transferrin receptor binding molecular_function
Process(es)
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of peptide antigen via MHC class I cellular iron ion homeostasis acute-phase response immune response female pregnancy cellular response to iron ion starvation antigen processing and presentation hormone biosynthetic process iron ion homeostasis multicellular organismal iron ion homeostasis liver regeneration iron ion import into cell response to iron ion starvation immune system process positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of receptor binding negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of T cell antigen processing and presentation negative regulation of T cell cytokine production protein complex assembly response to iron ion positive regulation of protein binding positive regulation of receptor-mediated endocytosis cellular response to iron ion positive regulation of peptide hormone secretion positive regulation of receptor binding positive regulation of ferrous iron import into cell negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I positive regulation of ferrous iron binding positive regulation of transferrin receptor binding regulation of protein localization to cell surface negative regulation of receptor activity positive regulation of receptor activity negative regulation of CD8-positive, alpha-beta T cell activation
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