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Invitrogen
Granzyme K Polyclonal Antibody
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Product Details
PA5-50980
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
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Purification
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Product Specific Information
Granzyme K Polyclonal Antibody detects endogenous levels of Granzyme K protein.
Target Information
Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Fragmentin-3; granzyme 3; Granzyme K; granzyme K (granzyme 3; tryptase II); granzyme K (serine protease, granzyme 3; tryptase II); Granzyme-3; GrK; NK-Tryp-2; NK-tryptase-2; RNK-Tryp-2; tryptase II
Gene Aliases: GZMK; TRYP2
UniProt ID: (Human) P49863, (Mouse) O35205, (Rat) P49864
Entrez Gene ID: (Human) 3003, (Mouse) 14945, (Rat) 29165
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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