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Invitrogen
GRK2 Polyclonal Antibody
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Product Details
PA5-144889
Species Reactivity
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Type
Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: LVQWKKELRD AYREAQQLVQ RVPKMKNKPR SPVVELSKVP LVQRGSANGL
Antigen sequence identity: Mouse 98%; Rat 98%
Target Information
ADRBK1 (GRK2) is a serine/threonine kinase. Many of the G protein-coupled receptors are known to be phosphorylated by G protein-dependent receptor kinases (GRKs). G protein-coupled receptor kinases (GRKs) are important regulators of G protein-coupled receptors(GPCRs). GRK2 (83 kDa), one of six members of this family that have been identified, is ubiquitously expressed in mammals. After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs (e.g., a2-adrenergic receptor) are phosphorylated by GRKs. Internalization of the GPCRs, regulated by beta-arrestin-1, leads to activation of the Ras - Raf - ERK1&2 signaling pathway. GRK2 activity is tightly controlled by different mechanisms including phosphorylation by kinases such as PKC, Src and ERK1&2, as well as interaction with various proteins. ERK phosphorylates and thus inactivates GRK2 on serine 670 in a negative feedback mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: adrenergic beta receptor kinase 1; adrenergic, beta, receptor kinase 1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; EC 2.7.1.126; G-protein coupled receptor kinase 2; grk 2
Gene Aliases: ADRBK1; BARK; BARK1; BETA-ARK1; GRK2
UniProt ID: (Human) P25098
Entrez Gene ID: (Human) 156
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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