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Invitrogen
P2Y14 Polyclonal Antibody
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Product Details
PA5-34087
Species Reactivity
Published species
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Immunogen
Conjugate
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Product Specific Information
Percent identity with other species by BLAST analysis: Human (100%) Monkey (95%).
Target Information
GPR105 has been reported to be expressed in brain. ESTs have been isolated from kidney, placenta, uterus, and heart/melanocyte/uterus libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G protein coupled receptor for UDP-glucose; G protein-coupled receptor 105; G-protein coupled receptor 105; GPCR105; P2Y purinoceptor 14; P2Y(14) receptor; P2Y14; P2Y14 receptor; purinergic receptor P2Y, G-protein coupled, 14; UDP-glucose receptor; VTR 15-20 receptor
Gene Aliases: BPR105; GPR105; KIAA0001; P2RY14; P2Y14
UniProt ID: (Human) Q15391
Entrez Gene ID: (Human) 9934
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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