Invitrogen

GLI2 Recombinant Superclonal™ Antibody (9HCLC)

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Datasheet
Protocols
Questions & Answers
GLI2 Recombinant Superclonal™ Antibody (9HCLC)

Product Details

711045

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

9HCLC

Immunogen

Protein corresponding to Human GLI2 (aa 1-332)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633108

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Bovine and Rabbit

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

Gli-2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GLI family zinc finger protein 2; GLI-Kruppel family member GLI2; glioma-associated oncogene family zinc finger 2; oncogene GLI2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; Zinc finger protein GLI2

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Gene Aliases: AW546128; CJS; GLI2; HPE9; PHS2; THP; THP1; THP2

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UniProt ID: (Human) P10070, (Mouse) Q0VGT2

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Entrez Gene ID: (Human) 2736, (Rat) 304729, (Mouse) 14633

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding molecular_function DNA binding transcription regulatory region DNA binding nucleic acid binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation in utero embryonic development kidney development morphogenesis of an epithelium chondrocyte differentiation osteoblast development transcription from RNA polymerase II promoter smoothened signaling pathway pattern specification process axon guidance ventral midline development hindgut morphogenesis heart development cell proliferation positive regulation of cell proliferation regulation of smoothened signaling pathway response to mechanical stimulus epidermal cell differentiation dorsal/ventral pattern formation proximal/distal pattern formation floor plate formation spinal cord dorsal/ventral patterning ventral spinal cord development spinal cord motor neuron differentiation cerebellar cortex morphogenesis smoothened signaling pathway involved in ventral spinal cord interneuron specification smoothened signaling pathway involved in spinal cord motor neuron cell fate specification dorsal/ventral neural tube patterning neural tube development smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation spinal cord ventral commissure morphogenesis pituitary gland development cell differentiation lung development mammary gland development hindbrain development negative regulation of chondrocyte differentiation tube development odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of neuron differentiation positive regulation of DNA replication positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract development developmental growth anatomical structure formation involved in morphogenesis neuron development branching morphogenesis of an epithelial tube anatomical structure development notochord regression head development prostatic bud formation mammary gland duct morphogenesis smoothened signaling pathway involved in dorsal/ventral neural tube patterning cellular response to organic cyclic compound cochlea morphogenesis cellular response to virus anterior/posterior pattern specification positive regulation of T cell differentiation in thymus negative regulation of apoptotic process transcription, DNA-templated regulation of transcription, DNA-templated
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