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Proteintech
GCAP1 Polyclonal Antibody
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Product Details
12944-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Shipping conditions
Product Specific Information
Immunogen sequence: MGNVMEGKS VEELSSTECH QWYKKFMTEC PSGQLTLYEF RQFFGLKNLS PSASQYVEQM FETFDFNKDG YIDFMEYVAA LSLVLKGKVE QKLRWYFKLY DVDGNGCIDR DELLTIIQAI RAINPCSDTT MTAEEFTDTV FSKIDVNGDG ELSLEEFIEG VQKDQMLLDT LTRSLDLTRI VRRLQNGEQD EEGADEAAEA AG (1-201 aa encoded by BC031663)
Target Information
Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90% similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: cone dystrophy 3; GCAP 1; Guanylate cyclase activator 1A; guanylate cyclase-activating protein, photoreceptor 1; guanylin 1, retina; Guanylyl cyclase-activating protein 1
Gene Aliases: C6orf131; COD3; CORD14; GC-A; GCAP; GCAP1; GUCA; GUCA1; GUCA1A; mGCAP1
UniProt ID: (Human) P43080, (Mouse) P43081
Entrez Gene ID: (Human) 2978, (Mouse) 14913, (Rat) 301233
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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