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Proteintech
GABRA1 Polyclonal Antibody
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Product Details
12410-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: LTGRSYGQP SLQDELKDNT TVFTRILDRL LDGYDNRLRP GLGERVTEVK TDIFVTSFGP VSDHDMEYTI DVFFRQSWKD ERLKFKGPMT VLRLNNLMAS KIWTPDTFFH NGKKSVAHNM TMPNKLLRIT EDGTLLYTMR LTVRAECPMH LEDFPMDAHA CPLKFGSYAY TRAEVVYEWT REPARSVVVA EDGSRLNQYD LLGQTVDSGI VQSSTGEYVV MTTHFHLKRK IGYFVIQTYL PCIMTVILSQ VSFWLNRESV P (21-280 aa encoded by BC030696)
Target Information
Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABAA alpha 1; GABAAR alpha1; GABAAR subunit alpha-1; GABRA 1; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; gamma-aminobutyric acid A receptor, alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1
Gene Aliases: ECA4; EIEE19; EJM; EJM5; Gabra-1; GABRA1
UniProt ID: (Human) P14867, (Rat) P62813, (Mouse) P62812
Entrez Gene ID: (Human) 2554, (Rat) 29705, (Mouse) 14394
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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