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  • Primary Antibodies ›
  • FTO Antibodies

Invitrogen

FTO Polyclonal Antibody

View all (23) FTO antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite FTO Polyclonal Antibody

FTO Polyclonal Antibody

Product Details

PA5-51074

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1:20,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from the N-terminal region of human FTO.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2636522

Product Specific Information

FTO Polyclonal Antibody detects endogenous levels of FTO protein.

Target Information

FTO is a novel protein and a member of the non-heme dioxygenase (Fe(II)-and 2-oxoglutarate-dependent dioxygenases) superfamily. Amino acid conservation patterns support this hypothesis and indicates that both 2-oxoglutarate and iron should be important for FTO function. Though not much is yet known about FTO, it is thought that the protein may somehow modify the activity of genes involved in metabolism and fat storage, which in turn may influence a person's risk of obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AlkB homolog 9; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein; fatso; m6A(m)-demethylase FTO; MGC5149; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; Protein fatso; protein fto; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

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Gene Aliases: ALKBH9; AW743446; BMIQ14; FTO; GDFD; KIAA1752; mKIAA1752; RGD1305121

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UniProt ID: (Human) Q9C0B1, (Rat) Q2A121, (Mouse) Q8BGW1

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Entrez Gene ID: (Human) 79068, (Rat) 291905, (Mouse) 26383

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Function(s)
ferrous iron binding oxidative RNA demethylase activity oxidative DNA demethylase activity DNA-N1-methyladenine dioxygenase activity RNA N6-methyladenosine dioxygenase activity molecular_function sulfonate dioxygenase activity oxidoreductase activity 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity procollagen-proline dioxygenase activity hypophosphite dioxygenase activity metal ion binding dioxygenase activity C-19 gibberellin 2-beta-dioxygenase activity C-20 gibberellin 2-beta-dioxygenase activity
Process(es)
temperature homeostasis DNA dealkylation involved in DNA repair regulation of lipid storage oxidative single-stranded DNA demethylation oxidative single-stranded RNA demethylation regulation of multicellular organism growth RNA repair regulation of respiratory system process adipose tissue development regulation of white fat cell proliferation oxidative demethylation DNA demethylation regulation of brown fat cell differentiation DNA repair cellular response to DNA damage stimulus oxidation-reduction process
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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