Invitrogen

FOXJ1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
FOXJ1 Polyclonal Antibody

Product Details

PA5-52189

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FOXJ1. Recombinant protein control fragment (Product #RP-102512).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2641716

Product Specific Information

Immunogen sequence: PREKDEPGKG GFWRIDPQYA ERLLSGAFKK RRLPPVHIHP AFARQAAQEP SAVPRAGPLT VNTEAQQLLR EFEEATGEAG WGAGEGRLGH KRKQPLPKRV AKVPRPPSTL LPTPEEQGEL EPLKG

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 29%.

Target Information

Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity, through the repression of NF B activity. FOXJ1 also inhibits the humoral immune response in B cells. FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: fork head homologue 4; Forkhead box protein J1; forkhead transcription factor HFH-4; forkhead-like 13; Forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4; HFH-4; MGC35202

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Gene Aliases: FKHL13; FOXJ1; HFH-4; HFH4

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UniProt ID: (Human) Q92949

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Entrez Gene ID: (Human) 2302

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter central tolerance induction negative regulation of germinal center formation positive regulation of central B cell tolerance induction negative regulation of humoral immune response mediated by circulating immunoglobulin transcription from RNA polymerase II promoter humoral immune response spermatogenesis determination of left/right symmetry pattern specification process brain development heart development actin cytoskeleton organization negative regulation of NF-kappaB transcription factor activity negative regulation of T cell differentiation in thymus establishment of apical/basal cell polarity metanephric part of ureteric bud development negative regulation of T cell proliferation cilium assembly negative regulation of interleukin-6 biosynthetic process positive regulation of transcription from RNA polymerase II promoter negative regulation of B cell activation leukocyte migration cilium morphogenesis lung epithelium development epithelium development left/right pattern formation glomerular parietal epithelial cell development activation of GTPase activity positive regulation of lung ciliated cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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