Invitrogen

FOXA2 Monoclonal Antibody (7H4B7)

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View all (33) FOXA2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-15542

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7H4B7

Immunogen

Purified recombinant fragment of FOXA2 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979228

Product Specific Information

MA5-15542 targets FOXA2 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.

The MA5-15542 immunogen is purified recombinant fragment of FOXA2 expressed in E. Coli.

MA5-15542 detects FOXA2 which has a predicted molecular weight of approximately 48kDa.

Target Information

FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3 beta (winged helix transcription factor); hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; WHN

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Gene Aliases: FOXA2; Hnf-3b; HNF3-beta; HNF3B; HNF3beta; Tcf-3b; TCF3B

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UniProt ID: (Human) Q9Y261, (Mouse) P35583

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Entrez Gene ID: (Human) 3170, (Mouse) 15376

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding protein domain specific binding transcription regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding double-stranded DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding kinase binding sequence-specific DNA binding SMAD binding
Process(es)
positive regulation of transcription from RNA polymerase II promoter by glucose negative regulation of transcription from RNA polymerase II promoter by glucose in utero embryonic development ectoderm formation cell fate specification transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development pattern specification process adult locomotory behavior anatomical structure morphogenesis anterior/posterior pattern specification dorsal/ventral pattern formation regulation of gene expression negative regulation of epithelial to mesenchymal transition chromatin modification regulation of lipid metabolic process regulation of steroid metabolic process cell differentiation in hindbrain dorsal/ventral neural tube patterning signal transduction involved in regulation of gene expression regulation of blood coagulation lung development endocrine pancreas development somite rostral/caudal axis specification negative regulation of glucokinase activity positive regulation of embryonic development negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter cell development anatomical structure formation involved in morphogenesis neuron fate specification epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation regulation of insulin secretion involved in cellular response to glucose stimulus connective tissue development response to interleukin-6 dopaminergic neuron differentiation primitive streak formation positive regulation of gastrulation negative regulation of detection of glucose covalent chromatin modification positive regulation of cell-cell adhesion mediated by cadherin
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