OriGene

FOS Monoclonal Antibody (UMAB221), UltraMAB™

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Datasheet
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Datasheet
Protocols
Questions & Answers
FOS Monoclonal Antibody (UMAB221), UltraMAB™

Product Details

UM800113

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200
-

ChIP assay (ChIP)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

UMAB221

Immunogen

Full length human recombinant protein of human FOS produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.0 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activator protein 1; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; Fos proto-oncogene, AP-1 trancription factor subunit; Fos proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 7; Protein c-Fos; Proto-oncogene c-Fos; Transcription factor AP-1 subunit c-Fos

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Gene Aliases: AP-1; C-FOS; FOS; G0S7; p55

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UniProt ID: (Human) P01100

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Entrez Gene ID: (Human) 2353

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding transcription regulatory region DNA binding protein heterodimerization activity R-SMAD binding
Process(es)
conditioned taste aversion DNA methylation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response transforming growth factor beta receptor signaling pathway nervous system development female pregnancy aging response to cold response to light stimulus response to gravity response to toxic substance sleep cellular response to extracellular stimulus response to lipopolysaccharide response to progesterone cellular response to hormone stimulus response to cytokine cellular response to reactive oxygen species response to immobilization stress skeletal muscle cell differentiation response to muscle stretch Fc-epsilon receptor signaling pathway response to drug positive regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of sequence-specific DNA binding transcription factor activity response to corticosterone response to cAMP SMAD protein signal transduction cellular response to calcium ion positive regulation of pri-miRNA transcription from RNA polymerase II promoter
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